BALE LAB
.svg){kind=icon}
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects
Montgomery KR, Bridi MS, Folts LM, Marx-Rattner R, Zierden HC, Wulff AB, Kodjo EA, Thompson SM, Bale TL. Neuropsychopharmacology. 2023 Oct 13. doi: 10.1038/s41386-023-01739-5. Epub ahead of print. PMID: 37833589.
2023
How Sucrose Preference Is Gained and Lost: An In-Depth Analysis of Drinking Behavior during the Sucrose Preference Test in Mice
Wulff AB, Cooper P, Kodjo E, Abel E, Thompson SM. How Sucrose Preference Is Gained and Lost: An In-Depth Analysis of Drinking Behavior during the Sucrose Preference Test in Mice. eNeuro. 2023 Sep 28;10(9):ENEURO.0195-23.2023. doi: 10.1523/ENEURO.0195-23.2023. PMID: 37699705; PMCID: PMC10540674.
2023
What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons
Cole AB, Montgomery K, Bale TL, Thompson SM. What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons. Neurobiol Stress. 2022 Aug 5;20:100473. doi: 10.1016/j.ynstr.2022.100473. PMID: 35982732; PMCID: PMC9379952.
2022
Negative allosteric modulation of GABAARs at α5 subunit- containing benzodiazepine sites reverses stress-induced anhedonia and weakened synaptic function in mice
Troppoli TA, Zanos P, Georgiou P, Gould TD, Rudolph U, Thompson SM. Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. Biol Psychiatry. 2022 Aug 1;92(3):216-226. doi: 10.1016/j.biopsych.2021.11.024. Epub 2021 Dec 15. PMID: 35120711; PMCID: PMC9198111.
2022
Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice
Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson SM. Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2022489118. doi: 10.1073/pnas.2022489118. PMID: 33850049; PMCID: PMC8092378.
2021
Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain
Morrison KE, Cole AB, Kane PJ, Meadows VE, Thompson SM, Bale TL. Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain. Neuropsychopharmacology. 2020 Jul;45(8):1263-1271. doi: 10.1038/s41386-020-0634-y. Epub 2020 Feb 11. PMID: 32045935; PMCID: PMC7297802.
2020
Brexanolone for the treatment of patients with postpartum depression
Morrison KE, Cole AB, Thompson SM, Bale TL. Brexanolone for the treatment of patients with postpartum depression. Drugs Today (Barc). 2019 Sep;55(9):537-544. doi: 10.1358/dot.2019.55.9.3040864. PMID: 31584571; PMCID: PMC8033597.
2019
The critical importance of basic animal research for neuropsychiatric disorders
Bale TL, Abel T, Akil H, Carlezon WA Jr, Moghaddam B, Nestler EJ, Ressler KJ, Thompson SM. The critical importance of basic animal research for neuropsychiatric disorders. Neuropsychopharmacology. 2019 Jul;44(8):1349-1353. doi: 10.1038/s41386-019-0405-9. Epub 2019 May 2. PMID: 31048727; PMCID: PMC6784904.
2019
Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants
Gould TD, Zarate CA Jr, Thompson SM. Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants. Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:213-236. doi: 10.1146/annurev-pharmtox-010617-052811. Epub 2018 Oct 8. PMID: 30296896; PMCID: PMC6364552.
2019
Reward behavior is regulated by the strength of hippocampus- nucleus accumbens synapses
LeGates TA, Kvarta MD, Tooley JR, Francis TC, Lobo MK, Creed MC, Thompson SM. Reward behaviour is regulated by the strength of hippocampus-nucleus accumbens synapses. Nature. 2018 Dec;564(7735):258-262. doi: 10.1038/s41586-018-0740-8. Epub 2018 Nov 26. PMID: 30478293; PMCID: PMC6292781.
2018
A Negative Allosteric Modulator for alpha5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice
Zanos P, Nelson ME, Highland JN, Krimmel SR, Georgiou P, Gould TD, Thompson SM. A Negative Allosteric Modulator for α5 Subunit-Containing GABA Receptors Exerts a Rapid and Persistent Antidepressant-Like Action without the Side Effects of the NMDA Receptor Antagonist Ketamine in Mice. eNeuro. 2017 Mar 7;4(1):ENEURO.0285-16.2017. doi: 10.1523/ENEURO.0285-16.2017. PMID: 28275719; PMCID: PMC5334634.
2017
NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KS, Fang Y, Huang XP, Mayo CL, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA Jr, Gould TD. NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature. 2016 May 26;533(7604):481-6. doi: 10.1038/nature17998. Epub 2016 May 4. PMID: 27144355; PMCID: PMC4922311.
2016
Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors
Fischell J, Van Dyke AM, Kvarta MD, LeGates TA, Thompson SM. Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors. Neuropsychopharmacology. 2015 Oct;40(11):2499-509. doi: 10.1038/npp.2015.112. Epub 2015 Apr 22. PMID: 25900119; PMCID: PMC4569955.
2015
An excitatory synapse hypothesis of depression
Thompson SM, Kallarackal AJ, Kvarta MD, Van Dyke AM, LeGates TA, Cai X. An excitatory synapse hypothesis of depression. Trends Neurosci. 2015 May;38(5):279-94. doi: 10.1016/j.tins.2015.03.003. Epub 2015 Apr 14. PMID: 25887240; PMCID: PMC4417609.
2015
Chronic Stress Induces a Selective Decrease in AMPA Receptor-Mediated Synaptic Excitation at Hippocampal Temporoammonic-CA1 Synapses
Kallarackal AJ, Kvarta MD, Cammarata E, Jaberi L, Cai X, Bailey AM, Thompson SM. Chronic stress induces a selective decrease in AMPA receptor-mediated synaptic excitation at hippocampal temporoammonic-CA1 synapses. J Neurosci. 2013 Oct 2;33(40):15669-74. doi: 10.1523/JNEUROSCI.2588-13.2013. PMID: 24089474; PMCID: PMC3787493.
2013
Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression
Cai X, Kallarackal AJ, Kvarta MD, Goluskin S, Gaylor K, Bailey AM, Lee HK, Huganir RL, Thompson SM. Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression. Nat Neurosci. 2013 Apr;16(4):464-72. doi: 10.1038/nn.3355. Epub 2013 Mar 17. PMID: 23502536; PMCID: PMC3609911.
2013