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Stress increases sperm respiration andmotility in mice and men
Moon N, Morgan CP, Marx-Rattner R, Jeng A, Johnson RL, Chikezie I, Mannella C, Sammel MD, Epperson CN, Bale TL. Stress increases sperm respiration and motility in mice and men. Nat Commun 15, 7900 (2024). doi: 10.1038/s41467-024-52319-0
2024
Chemogenetic activation of CRF neurons as a model of chronic stress produces sex-specific physiological and behavioral effects
Montgomery KR, Bridi MS, Folts LM, Marx-Rattner R, Zierden HC, Wulff AB, Kodjo EA, Thompson SM, Bale TL. Neuropsychopharmacology. 2023 Oct 13. doi: 10.1038/s41386-023-01739-5. Epub ahead of print. PMID: 37833589.
2023
Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy
Zierden HC, Marx-Rattner R, Rock KD, Montgomery KR, Anastasiadis P, Folts L, Bale TL. Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy. Sci Rep. 2023 Mar 20;13(1):4568. doi: 10.1038/s41598-023-31425-x. PMID: 36941297; PMCID: PMC10027885.
2023
Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specifc manner
Duffy KA, Sammel MD, Johnson RL, Kim DR, Wang EY, Ewing G, Hantsoo L, Kornfield SL, Bale TL, Epperson CN. Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner. Biol Sex Differ. 2023 Feb 17;14(1):7. doi: 10.1186/s13293-023-00492-0. PMID: 36803442; PMCID: PMC9936707.
2023
HA‐tag CD63 is a novel conditional transgenic approach to track extracellular vesicle interactions with sperm and their transfer at conception
Morgan CP, Meadows VE, Marx-Rattner R, Cisse YM, Bale TL. HA-tag CD63 is a novel conditional transgenic approach to track extracellular vesicle interactions with sperm and their transfer at conception. Sci Rep. 2023 Jan 13;13(1):707. doi: 10.1038/s41598-023-27898-5. PMID: 36639735; PMCID: PMC9839718.
2023
What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons
Cole AB, Montgomery K, Bale TL, Thompson SM. What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons. Neurobiol Stress. 2022 Aug 5;20:100473. doi: 10.1016/j.ynstr.2022.100473. PMID: 35982732; PMCID: PMC9379952.
2022
Developmental timing of trauma in women predicts unique extracellular vesicle proteome signatures
Morrison KE, Stenson AF, Marx-Rattner R, Carter S, Michopoulos V, Gillespie CF, Powers A, Huang W, Kane MA, Jovanovic T, Bale TL. Developmental Timing of Trauma in Women Predicts Unique Extracellular Vesicle Proteome Signatures. Biol Psychiatry. 2022 Feb 1;91(3):273-282. doi: 10.1016/j.biopsych.2021.08.003. Epub 2021 Aug 17. PMID: 34715991; PMCID: PMC9219961.
2022
Germ Cell Drivers: Transmission of Preconception Stress Across Generations
Duffy KA, Bale TL, Epperson CN. Germ Cell Drivers: Transmission of Preconception Stress Across Generations. Front Hum Neurosci. 2021 Jul 12;15:642762. doi: 10.3389/fnhum.2021.642762. PMID: 34322003; PMCID: PMC8311293.
2021
The critical importance in identifying the biological mechanisms underlying the effects of racism on mental health
Bale TL, Jovanovic T. The critical importance in identifying the biological mechanisms underlying the effects of racism on mental health. Neuropsychopharmacology. 2021 Jan;46(1):233. doi: 10.1038/s41386-020-00801-w. PMID: 32792682; PMCID: PMC7424557.
2021
Repeated sampling facilitates within- and between-subject modeling of the human sperm transcriptome to identify dynamic and stress-responsive sncRNAs
Morgan CP, Shetty AC, Chan JC, Berger DS, Ament SA, Epperson CN, Bale TL. Repeated sampling facilitates within- and between-subject modeling of the human sperm transcriptome to identify dynamic and stress-responsive sncRNAs. Sci Rep. 2020 Oct 15;10(1):17498. doi: 10.1038/s41598-020-73867-7. PMID: 33060642; PMCID: PMC7562703.
2020
Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific
Cissé YM, Chan JC, Nugent BM, Banducci C, Bale TL. Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific. Placenta. 2020 Oct;100:164-170. doi: 10.1016/j.placenta.2020.06.019. Epub 2020 Jul 12. PMID: 32980048; PMCID: PMC7525040.
2020
Microphysiological systems of the placental barrier
Arumugasaamy N, Rock KD, Kuo CY, Bale TL, Fisher JP. Microphysiological systems of the placental barrier. Adv Drug Deliv Rev. 2020;161-162:161-175. doi: 10.1016/j.addr.2020.08.010. Epub 2020 Aug 26. PMID: 32858104; PMCID: PMC10288517.
2020
Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression
Ramsteijn AS, Jašarević E, Houwing DJ, Bale TL, Olivier JD. Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression. Gut Microbes. 2020 Jul 3;11(4):735-753. doi: 10.1080/19490976.2019.1705728. Epub 2020 Jan 23. PMID: 31971855; PMCID: PMC7524305.
2020
Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain
Morrison KE, Cole AB, Kane PJ, Meadows VE, Thompson SM, Bale TL. Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain. Neuropsychopharmacology. 2020 Jul;45(8):1263-1271. doi: 10.1038/s41386-020-0634-y. Epub 2020 Feb 11. PMID: 32045935; PMCID: PMC7297802.
2020
Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment
Chan JC, Morgan CP, Adrian Leu N, Shetty A, Cisse YM, Nugent BM, Morrison KE, Jašarević E, Huang W, Kanyuch N, Rodgers AB, Bhanu NV, Berger DS, Garcia BA, Ament S, Kane M, Neill Epperson C, Bale TL. Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment. Nat Commun. 2020 Mar 20;11(1):1499. doi: 10.1038/s41467-020-15305-w. PMID: 32198406; PMCID: PMC7083921.
2020
Brexanolone for the treatment of patients with postpartum depression
Morrison KE, Cole AB, Thompson SM, Bale TL. Brexanolone for the treatment of patients with postpartum depression. Drugs Today (Barc). 2019 Sep;55(9):537-544. doi: 10.1358/dot.2019.55.9.3040864. PMID: 31584571; PMCID: PMC8033597.
2019
The critical importance of basic animal research for neuropsychiatric disorders
Bale TL, Abel T, Akil H, Carlezon WA Jr, Moghaddam B, Nestler EJ, Ressler KJ, Thompson SM. The critical importance of basic animal research for neuropsychiatric disorders. Neuropsychopharmacology. 2019 Jul;44(8):1349-1353. doi: 10.1038/s41386-019-0405-9. Epub 2019 May 2. PMID: 31048727; PMCID: PMC6784904.
2019
Driving the next generation: Paternal lifetime experiences transmitted via extracellular vesicles and their small RNA cargo
Morgan CP, Chan JC, Bale TL. Driving the Next Generation: Paternal Lifetime Experiences Transmitted via Extracellular Vesicles and Their Small RNA Cargo. Biol Psychiatry. 2019 Jan 15;85(2):164-171. doi: 10.1016/j.biopsych.2018.09.007. Epub 2018 Sep 27. PMID: 30580777; PMCID: PMC6309802.
2019
Sex matters
Bale TL. Sex matters. Neuropsychopharmacology. 2019 Jan 1;44(1):1-3. doi: 10.1038/s41386-018-0239-x.
2019
Placental H3K27me3 establishes female resilience to prenatal insults
Nugent BM, O'Donnell CM, Epperson CN, Bale TL. Placental H3K27me3 establishes female resilience to prenatal insults. Nat Commun. 2018 Jul 2;9(1):2555. doi: 10.1038/s41467-018-04992-1. PMID: 29967448; PMCID: PMC6028627.
2018
Parental advisory: maternal and paternal stress can impact offspring neurodevelopment
Chan JC, Nugent BM, Bale TL. Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment. Biol Psychiatry. 2018 May 15;83(10):886-894. doi: 10.1016/j.biopsych.2017.10.005. Epub 2017 Oct 13. PMID: 29198470; PMCID: PMC5899063.
2018
Strained in Planning Your Mouse Background? Using the HPA Stress Axis as a Biological Readout for Backcrossing Strategies
Chan JC, Houghton AB, Bale TL. Strained in Planning Your Mouse Background? Using the HPA Stress Axis as a Biological Readout for Backcrossing Strategies. Neuropsychopharmacology. 2017 Aug;42(9):1749-1751. doi: 10.1038/npp.2017.66. Epub 2017 Mar 31. PMID: 28361869; PMCID: PMC5520787.
2017
Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating
Bronson SL, Chan JC, Bale TL. Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating. Biol Psychiatry. 2017 Jul 15;82(2):127-138. doi: 10.1016/j.biopsych.2016.12.025. Epub 2016 Dec 30. PMID: 28168960; PMCID: PMC5483189.
2017
Preadolescent adversity programs a disrupted maternal stress reactivity in humans and mice
Morrison KE, Epperson CN, Sammel MD, Ewing G, Podcasy JS, Hantsoo L, Kim DR, Bale TL. Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice. Biol Psychiatry. 2017 Apr 15;81(8):693-701. doi: 10.1016/j.biopsych.2016.08.027. Epub 2016 Aug 26. PMID: 27776734; PMCID: PMC5326692.
2017
Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition
Epperson CN, Sammel MD, Bale TL, Kim DR, Conlin S, Scalice S, Freeman K, Freeman EW. Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition. J Clin Psychiatry. 2017 Mar;78(3):e298-e307. doi: 10.4088/JCP.16m10662. PMID: 28394509.
2017
Sex as a Biological Variable: Who, What, When, Why, and How
Bale TL, Epperson CN. Sex as a Biological Variable: Who, What, When, Why, and How. Neuropsychopharmacology. 2017 Jan;42(2):386-396. doi: 10.1038/npp.2016.215. Epub 2016 Sep 23. PMID: 27658485; PMCID: PMC5399243.
2017
The placenta and neurodevelopment: sex differences in prenatal vulnerability
Bale TL. The placenta and neurodevelopment: sex differences in prenatal vulnerability. Dialogues Clin Neurosci. 2016 Dec;18(4):459-464. doi: 10.31887/DCNS.2016.18.4/tbale. PMID: 28179817; PMCID: PMC5286731.
2016
Sex differences in the gut microbiome – brain axis across the lifespan
Jašarević E, Morrison KE, Bale TL. Sex differences in the gut microbiome-brain axis across the lifespan. Philos Trans R Soc Lond B Biol Sci. 2016 Feb 19;371(1688):20150122. doi: 10.1098/rstb.2015.0122. Epub 2016 Feb 1. PMID: 26833840; PMCID: PMC4785905.
2016
Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
Rodgers AB, Morgan CP, Leu NA, Bale TL. Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13699-704. doi: 10.1073/pnas.1508347112. Epub 2015 Oct 19. PMID: 26483456; PMCID: PMC4640733.
2015
Sex differences and stress across the lifespan
Bale TL, Epperson CN. Sex differences and stress across the lifespan. Nat Neurosci. 2015 Oct;18(10):1413-20. doi: 10.1038/nn.4112. Epub 2015 Sep 25. PMID: 26404716; PMCID: PMC4620712.
2015
Germ cell origins of PTSD risk: the transgenerational impact of parental stress experience
Rodgers AB, Bale TL. Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience. Biol Psychiatry. 2015 Sep 1;78(5):307-14. doi: 10.1016/j.biopsych.2015.03.018. Epub 2015 Mar 23. PMID: 25895429; PMCID: PMC4526334.
2015
Epigenetic and transgenerational reprogramming of brain development
Bale TL. Epigenetic and transgenerational reprogramming of brain development. Nat Rev Neurosci. 2015 Jun;16(6):332-44. doi: 10.1038/nrn3818. Epub 2015 Apr 29. PMID: 25921815; PMCID: PMC7064155.
2015
Prenatal Programming of Mental Illness: Current Understanding of Relationship and Mechanisms
Kim DR, Bale TL, Epperson CN. Prenatal programming of mental illness: current understanding of relationship and mechanisms. Curr Psychiatry Rep. 2015 Feb;17(2):5. doi: 10.1007/s11920-014-0546-9. PMID: 25617041; PMCID: PMC4458064.
2015
Lifetime stress experience: transgenerational epigenetics and germ cell programming
Bale TL. Lifetime stress experience: transgenerational epigenetics and germ cell programming. Dialogues Clin Neurosci. 2014 Sep;16(3):297-305. doi: 10.31887/DCNS.2014.16.3/tbale. PMID: 25364281; PMCID: PMC4214173.
2014
Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction
Howerton CL, Bale TL. Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9639-44. doi: 10.1073/pnas.1401203111. Epub 2014 Jun 16. PMID: 24979775; PMCID: PMC4084439.
2014
Epigenetic mechanisms in pubertal brain maturation
Morrison KE, Rodgers AB, Morgan CP, Bale TL. Epigenetic mechanisms in pubertal brain maturation. J Neurosci. 2014 Apr 4;264:17-24. doi: 10.1016/j.neuroscience.2013.11.014. Epub 2013 Nov 15. PMID: 24239720; PMCID: PMC3959229.
2014
Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms OffspringHPAStress Axis Regulation
Rodgers AB, Morgan CP, Bronson SL, Revello S, Bale TL. Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation. J Neurosci. 2013 May 22;33(21):9003-12. doi: 10.1523/JNEUROSCI.0914-13.2013. PMID: 23699511; PMCID: PMC3712504.
2013
Minireview: CRF and Wylie Vale: A Story of 41 Amino Acids and a Texan with Grit
Bale TL, Chen A. Minireview: CRF and Wylie Vale: a story of 41 amino acids and a Texan with grit. Endocrinology. 2012 Jun;153(6):2556-61. doi: 10.1210/en.2012-1273. Epub 2012 Apr 4. PMID: 22492308; PMCID: PMC3359597.
2012
Early Prenatal Stress Epigenetically Programs Dysmasculinization in Second-Generation Offspring via the Paternal Lineage
Morgan CP, Bale TL. Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage. J Neurosci. 2011 Aug 17;31(33):11748-55. doi: 10.1523/JNEUROSCI.1887-11.2011. PMID: 21849535; PMCID: PMC3164823.
2011
Sex differences in prenatal epigenetic programing of stress pathways
Bale TL. Sex differences in prenatal epigenetic programming of stress pathways. Stress. 2011 Jul;14(4):348-56. doi: 10.3109/10253890.2011.586447. PMID: 21663536.
2011
Early life programming and neurodevelopmental disorders
Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ. Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010 Aug 15;68(4):314-9. doi: 10.1016/j.biopsych.2010.05.028. PMID: 20674602; PMCID: PMC3168778.
2010
THOMPSON LAB
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